ПРОБЛЕМА АГРЕГАЦІЇ БІЛКОВИХ ПРЕПАРАТІВ ПРИ БІОФАРМАЦЕВТИЧНОМУ ВИРОБНИЦТВІ
Ключові слова:
protein aggregation, biopharmaceuticals, Quality by Design, Design of ExperimentsАнотація
Different mechanisms of protein molecule aggregation were reviewed. Aggregation represents a significant challenge in the field of biopharmaceuticals. We examine the problem of protein molecule aggregation, existing methods for its analysis and control, and strategies for minimizing aggregation at different drug development and manufacturing stages.
Посилання
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