FUSION PROTEINS IN BRAIN DRUG DELIVERY

Автор(и)

  • B. Ruzhytska National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Україна
  • O. Holembiovska National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Україна

Ключові слова:

fusion proteins, blood-brain barrier, protein therapeutics

Анотація

This paper reviews the use of fusion proteins for overcoming the blood-brain barrier in the treatment of central nervous system disorders. Various fusion protein strategies, including monoclonal antibodies and peptide fusion partners, are examined, highlighting their potential in enhancing CNS drug delivery.

Посилання

Strohl W. Chimeric genes, proteins. Reference module in life sciences. 2017. URL: https://doi.org/10.1016/b978-0-12-809633-8.06199-9.

Tuna M., Amos C. I., Mills G. B. Molecular mechanisms and pathobiology of oncogenic fusion transcripts in epithelial tumors. Oncotarget. 2019. Vol. 10, no. 21. P. 2095–2111. URL: https://doi.org/10.18632/oncotarget.26777.

Glick B. R., Patten C. L. Molecular biotechnology: principles and applications of recombinant DNA. ASM Press, 2022.

Marsh M. C., Owen S. C. Therapeutic fusion proteins. The AAPS Journal. 2023. Vol. 26, no. 1. URL: https://doi.org/10.1208/s12248-023-00873-8.

Boado R. J. IgG fusion proteins for brain delivery of biologics via blood–brain barrier receptor-mediated transport. Pharmaceutics. 2022. Vol. 14, no. 7. P. 1476. URL: https://doi.org/10.3390/pharmaceutics14071476.

A blood-brain-barrier-penetrating anti-human transferrin receptor antibody fusion protein for neuronopathic mucopolysaccharidosis II / H. Sonoda et al. Molecular therapy. 2018. Vol. 26, no. 5. P. 1366–1374. URL: https://doi.org/10.1016/j.ymthe.2018.02.032.

An affibody molecule is actively transported into the cerebrospinal fluid via binding to the transferrin receptor / S. W. Meister et al. International journal of molecular sciences. 2020. Vol. 21, no. 8. P. 2999. URL: https://doi.org/10.3390/ijms21082999.

VHHs as tools for therapeutic protein delivery to the central nervous system / Y. Wouters et al. Fluids and barriers of the CNS. 2022. Vol. 19, no. 1. URL: https://doi.org/10.1186/s12987-022-00374-4.

Tat-malate dehydrogenase fusion protein protects neurons from oxidative and ischemic damage by reduction of reactive oxygen species and modulation of glutathione redox system / H. J. Kwon et al. Scientific reports. 2023. Vol. 13, no. 1. URL: https://doi.org/10.1038/s41598-023-32812-0.

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Опубліковано

2024-05-17