DEVELOPMENT AND OPTIMISATION OF NUTRIENT MEDIA COMPOSITION FOR THE CULTIVATION OF ANTIBIOTIC PRODUCERS
Ключові слова:
Streptomyces, nutrient media optimization, Response Surface Methodology, secondary metabolites, antimicrobial resistance.Анотація
This study explores the multi-dimensional paradigms of bioprocess engineering, focusing on the statistical and empirical optimization of nutrient media for submerged cultivation of antibiotic-producing microorganismsfrom the genus Streptomyces. Special attention is given to Response Surface Methodology (RSM) and Central Composite Design (CCD). Case studies demonstrate significant yield improvements for chrysomycin A and herbicide 334-W4.
Посилання
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