FROM PLASTIC TO MEDICINE: BIOTECHNOLOGICAL CONVERSION OF PET INTO PARACETAMOL
Ключові слова:
paracetamol, PET, plastic waste, biotechnology, upcycling.Анотація
The article examines the global plastic crisis and explores biotechnological conversion of PET waste into paracetamol. It focuses on the use of engineered E. coli, alongside biocompatible reactions, to transform environmental pollutants into beneficial pharmaceuticals, highlighting potential applications in sustainable drug development.
Посилання
Li Shen, Ernst Worrell. Chapter 31 - Plastic recycling. Editor(s): Christina Meskers, Ernst Worrell, Markus A. Reuter, Handbook of Recycling (Second Edition), Elsevier, 2024, Pages 497-510, ISBN 9780323855143, https://doi.org/10.1016/B978-0-323-85514-3.00014-2.
Iwuozor, Kingsley. (2019). A Review on the Properties and Uses of Paracetamol. International Journal of Pharmacy and Chemistry. 5. 31-35. https://doi.org/10.11648/j.ijpc.20190503.12
Johnson, N.W., Valenzuela-Ortega, M., Thorpe, T.W. et al. A biocompatible Lossen rearrangement in Escherichia coli. Nat. Chem. 17, 1020–1026 (2025). https://doi.org/10.1038/s41557-025-01845-5
Howard, S.A., McCarthy, R.R. Modulating biofilm can potentiate activity of novel plastic-degrading enzymes. npj Biofilms Microbiomes 9, 72 (2023). https://doi.org/10.1038/s41522-023-00440-1
