IN SILICO АНАЛІЗ ТОКСИКОЛОГІЧНОГО ПРОФІЛЮ ТА ПОТЕНЦІЙНИХ ЛІКАРСЬКИХ ВЗАЄМОДІЙ НОВИХ ПОХІДНИХ ТОСУФЛОКСАЦИНУ
Ключові слова:
tosufloxacin derivatives, ADME/Tox, hepatotoxicity, drug-drug interactions, bioisosteric substitutions.Анотація
This study presents an in silico safety assessment of novel tosufloxacin derivatives with bioisosteric substitutions at N1 and C7. ADME/Tox tools were used to predict hepatotoxicity, mutagenicity, P-glycoprotein-related transport and potential drug-drug interactions. The analysis helped identify the most promising derivatives for further study.
Посилання
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