MECHANOTRANSDUCTION-BASED CALCIUM OSCILLATION CONTROL IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA VIA ROTATING MAGNETIC FIELDS AND NANOPARTICLES
Ключові слова:
magnetic field, magnetic nanoparticles, esophageal squamous cell carcinoma.Анотація
Rotating magnetic fields can modulate Ca2+ oscillation via magnetic nanoparticles as mechanotransducers in malignancies, thus falling below the Ca2+ decoding threshold required for Ras/ERK-mediated proliferation. Our ODE model extends KYSE-150 calcium dynamics. Additionally, conserved NOTCH-family mutations across ESCC subtypes support mechanosensitivity disruption as a general carcinogenic feature.
Посилання
Progressive study on the non-thermal effects of magnetic field therapy in oncology / A. Xu et al. Frontiers in oncology. 2021. Vol. 11. URL: https://doi.org/10.3389/fonc.2021.638146
Salatskyi Ye., Gorobets S. V., Gorobets O. Yu. Mathematical modelling of magnetic field and nanoparticle effects on calcium signalling in malignant esophageal cells. Biomedical physics & engineering express. 2025. URL: https://doi.org/10.1088/2057-1976/ae1140
Developing a mathematical model of intracellular calcium dynamics for evaluating combined anticancer effects of afatinib and RP4010 in esophageal cancer / Y. Chang et al. International journal of molecular sciences. 2022. Vol. 23, no. 3. P. 1763. URL: https://doi.org/10.3390/ijms23031763
Plank M. J., Wall D. J. N., David T. Atherosclerosis and calcium signalling in endothelial cells. Progress in biophysics and molecular biology. 2006. Vol. 91, no. 3. P. 287–313. URL: https://doi.org/10.1016/j.pbiomolbio.2005.07.005
Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields / O. Y. Gorobets et al. Nanoscale advances. 2024. URL: https://doi.org/10.1039/d3na01065a
Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis / J. Chang et al. Cancer cell. 2025. Vol. 43, no. 3. P. 380–397.e7. URL: https://doi.org/10.1016/j.ccell.2025.02.009
Ion channels and transporters in cancer. 4. Remodeling of Ca2+ signaling in tumorigenesis: role of Ca2+ transport / J. M. Lee et al. American journal of physiology-cell physiology. 2011. Vol. 301, no. 5. P. C969–C976. URL: https://doi.org/10.1152/ajpcell.00136.2011
NOTCH1 is a mechanosensor in adult arteries / J. J. Mack et al. Nature communications. 2017. Vol. 8, no. 1. URL: https://doi.org/10.1038/s41467-017-01741-8
A tr(i)p to cell migration: new roles of TRP channels in mechanotransduction and cancer / J. Canales et al. Frontiers in physiology. 2019. Vol. 10. URL: https://doi.org/10.3389/fphys.2019.00757
The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells / W. Wu et al. Cellular & molecular biology letters. 2018. Т. 23, № 1. URL: https://doi.org/10.1186/s11658-018-0102-4
Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin / B. Erdogan et al. Journal of cell biology. 2017. Vol. 216, no. 11. P. 3799–3816. URL: https://doi.org/10.1083/jcb.201704053
The genomic landscape of esophageal squamous cell carcinoma cell lines / C. Zhang et al. Cancer cell international. 2025. Vol. 25, no. 1. URL: https://doi.org/10.1186/s12935-025-03686-1
Interaction of magnetic fields with biogenic magnetic nanoparticles on cell membranes: physiological consequences for organisms in health and disease / O. Gorobets et al. Bioelectrochemistry. 2023. P. 108390. URL: https://doi.org/10.1016/j.bioelechem.2023.108390
Effects of static and low‐frequency magnetic fields on gene expression / V. Zablotskii et al. Journal of magnetic resonance imaging. 2025. URL: https://doi.org/10.1002/jmri.29726
Smedler E., Uhlén P. Frequency decoding of calcium oscillations. Biochimica et biophysica acta (BBA) - general subjects. 2014. Vol. 1840, no. 3. P. 964–969. URL: https://doi.org/10.1016/j.bbagen.2013.11.015
