ВПЛИВ ТЕТ НА ДИФЕРЕНЦІАЦІЮ СТОВБУРОВИХ КЛІТИН
Ключові слова:
TET proteins, stem cell differentiation, embryonic stem cells.Анотація
Differentiation is a critical process for tissue development during embryogenesis, as well as for tissue regeneration and repair in the adult body. Disruption of TET functions is associated with differentiation defects, changes in transcriptional programs and the development of pathologies, which emphasizes the need for a deeper understanding of the mechanisms of their action.
Посилання
López-Moyado I.F., Ko M., Hogan P.G. TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer. Annual Review of Immunotherapy. 2024. T. 42. C. 455-488. URL: https://doi.org/10.1146/annurev-immunol-080223-044610.
Wu X., Li G., Xie R. Decoding the role of TET family dioxygenases in lineage specification. Epigenetics & Chromatin. 2018. Т. 11, № 58. URL: https://doi.org/10.1186/s13072-018-0228-7.
Zhang X., Zhang Y., Wang C. TET (Ten-eleven translocation) family proteins: structure, biological functions and applications. Signal Transduction and Target Therapy. 2023. T. 8. C. 297. URL: https://doi.org/10.1038/s41392-023-01537-x.
Verma N., Pan H., Doré L.C. TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nature Genetics. 2018. T. 50, №1. C. 83–95. URL: https://doi.org/10.1038/s41588-017-0002-y.
Pantier R., Barbieri E., Brito S.G. TET knockout cells transit between pluripotent states and exhibit precocious germline entry. The EMBO Journal. 2025. T. 44, №23. C. 7060–7089. URL: https://doi.org/10.1038/s44318-025-00597-9.
Chrysanthou S., Tang Q., Lee J. The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity. Nucleic Acids Research. 2022. T. 50, № 6. C. 3169–3189. URL: https://doi.org/10.1093/nar/gkac089.
Beck D., Petracovici A., He C., Moore H. Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency. The American Journal of Human Genetics. 2020. T. 106, №2. С. 234-245. URL: https://doi.org/10.1016/j.ajhg.2019.12.007.
Wang L., You X., Ruan D., TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. 2022. T.13, №4709. URL: https://doi.org/10.1038/s41467-022-32138-x.
MacArthur I., Ma L., M. Dawlat . Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence. Science Advances. T. 10, № 35. URL: https://doi.org/10.1126/sciadv.ado5424.
