РЕГУЛЯЦІЯ ВТОРИННОГО МЕТАБОЛІЗМУ У PENICILLIUM SPP.: ВПЛИВ ДЖЕРЕЛ ВУГЛЕЦЮ ТА АЗОТУ НА СИНТЕЗ ГРИЗЕОФУЛЬВІНУ
Ключові слова:
secondary metabolism, carbon-nitrogen regulation, Penicillium spp., griseofulvin biosynthesis, nutrient sources.Анотація
This review summarizes current data on the effects of carbon and nitrogen sources on griseofulvin synthesis in Penicillium spp. It is shown that lactose and nitrate promote the activation of secondary metabolism, whereas glucose and ammonium inhibit polyketide synthesis via CreA- and AreA-dependent mechanisms.
Посилання
Aris P., Wei Y., Mohamadzadeh M., Xia X. Griseofulvin: An Updated Overview of Old and Current Knowledge. Molecules. 2022. Vol. 27, Issue 20. Article 7034. DOI: https://doi.org/10.3390/molecules27207034.
Keller N. P. Fungal secondary metabolism: regulation, function and drug discovery. Nature Reviews Microbiology. 2019. Vol. 17. P. 167-180. DOI: https://doi.org/10.1038/s41579-018-0121-1.
Chooi Y.-H., Cacho R. A., Tang Y. Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum. Chemistry & Biology. 2010. Vol. 17, Issue 5. P. 483-494. DOI: https://doi.org/10.1016/j.chembiol.2010.03.015.
Brakhage A. A., Schroeckh V. Fungal secondary metabolites – strategies to activate silent gene clusters. Fungal Genetics and Biology. 2011. Vol. 48, No. 1. P. 15-22. DOI: https://doi.org/10.1016/j.fgb.2010.04.004.
Strauss J., Reyes-Dominguez Y. Regulation of secondary metabolism by chromatin structure and epigenetic mechanisms. Fungal Genetics and Biology. 2011. Vol. 48, No. 1. P. 62-69. DOI: https://doi.org/10.1016/j.fgb.2010.07.009.
Ruijter G. J. G., Visser J. Carbon repression in Aspergillus. FEMS Microbiology Letters. 1997. Vol. 151. P. 103-114. DOI: https://doi.org/10.1111/j.1574-6968.1997.tb12557.x.
Zhang Y., Wang Y., Li Y., Chen Y., Zhang C., Yang K., Yin W.-B. The GATA factor AreB regulates nitrogen metabolism, fungal development, and aflatoxin production in Aspergillus flavus. Fungal Genetics and Biology. 2024. Vol. 180. Article 104878. DOI: https://doi.org/10.1016/j.fgb.2024.104878.
Marzluf G. A. Genetic regulation of nitrogen metabolism in fungi. Microbiological Reviews. 1997. Vol. 61, No. 1. P. 17-32. PMID: 9106362. URL: https://pubmed.ncbi.nlm.nih.gov/9106362/.
Demain A. L., Fang A. The natural functions of secondary metabolites. Advances in Biochemical Engineering/Biotechnology. 2000. Vol. 69. P. 1-39. DOI: https://doi.org/10.1007/3-540-44964-7_1.
Bode H. B., Bethe B., Höfs R., Zeeck A. Big effects from small changes: possible ways to explore nature’s chemical diversity. Chembiochem. 2002. Vol. 3, No. 7. P. 619-627. DOI: https://doi.org/10.1002/1439-7633(20020703)3:7<619::AID-CBIC619>3.0.CO;2-9.
Dowzer C. E. A., Kelly J. M. Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans. Molecular and General Genetics. 1991. Vol. 229, No. 1. P. 155-160. PMID: 1922072. DOI: https://doi.org/10.1007/BF00264225.
Ruijter G. J. G., Visser J. Carbon repression in Aspergillus niger: the role of glucose, lactose and maltose. FEMS Microbiology Reviews. 1997. Vol. 21, No. 2. P. 169-189. PMID: 9228741. DOI: https://doi.org/10.1111/j.1574-6976.1997.tb00350.x.
Sanchez J. F., Somoza A. D., Keller N. P., Wang C. C. C. Advances in Aspergillus secondary metabolite research in the post-genomic era. Natural Product Reports. 2012. Vol. 29. P. 351-371. DOI: https://doi.org/10.1039/c2np00084a.
Wong K. H., Hynes M. J., Davis M. A. Recent advances in nitrogen regulation: AreA and the GATA family of transcription factors in fungi. Fungal Biology Reviews. 2011. Vol. 25, No. 1. P. 1-10. DOI: https://doi.org/10.1016/j.fbr.2011.01.001.
Zhang L., Wang Y., Li Y., et al. Integration of Transcriptomic and Metabolomic Profiles Provides Insights into Nitrogen Regulation of Secondary Metabolism in Fusarium sacchari. International Journal of Molecular Sciences. 2023. Vol. 24, Issue 13. Article 10832. DOI: https://doi.org/10.3390/ijms241310832.
Tudzynski B. Nitrogen regulation of fungal secondary metabolism in plant pathogenic fungi. Annual Review of Phytopathology. 2005. Vol. 43. P. 43-67. DOI: https://doi.org/10.1146/annurev.phyto.43.040204.140214.
