THE ANTI-INFLAMMATORY POTENTIAL OF NANO-HYDROXYAPATITES
Ключові слова:
nanoparticles, apatite, zinc, copper, anti-inflammatory, antimicrobial activity, biomaterials.Анотація
Nanostructured hydroxyapatite is believed to be a promising scaffold material for dental and orthopedic implantation due to its biocompatibility and high osteoconductivity. Recent studies show that nHA has anti-inflammatory properties by modulating immune cell responses and reducing the expression of pro-inflammatory cytokines.
Посилання
Multicomponent adsorption of heavy metals onto biogenic hydroxyapatite: surface functional groups and inorganic mineral facilitating stable adsorption of Pb(Ⅱ) / X. Liu et al. Journal of Hazardous Materials. 2022. P. 130167. URL: https://doi.org/10.1016/j.jhazmat.2022.130167.
Duta L., Grumezescu V. The Effect of Doping on the Electrical and Dielectric Properties of Hydroxyapatite for Medical Applications: From Powders to Thin Films. Materials. 2024. Vol. 17, no. 3. P. 640. URL: https://doi.org/10.3390/ma17030640.
Study of microstructural and electrical properties of silver substituted hydroxyapatite for drug delivery applications / T. Chatterjee et al. Materials Today Communications. 2022. Vol. 31. P. 103360. URL: https://doi.org/10.1016/j.mtcomm.2022.103360.
The use of hydroxyapatite toothpaste to prevent dental caries / K. O’Hagan-Wong et al. Odontology. 2021. Vol. 110, no. 2. P. 223–230. URL: https://doi.org/10.1007/s10266-021-00675-4.
Biocompatible Nano-Hydroxyapatites Regulate Macrophage Polarization / D.-W. Zhao et al. Materials. 2022. Vol. 15, no. 19. P. 6986. URL: https://doi.org/10.3390/ma15196986.
Calcium Hydroxyapatite in Its Different Forms in Skin Tissue Repair: A Literature Review / P. T. E. Cruel et al. Surgeries. 2024. Vol. 5, no. 3. P. 640–659. URL: https://doi.org/10.3390/surgeries5030051.
A Novel Hydroxyapatite/Vitamin B12 Nanoformula for Treatment of Bone Damage: Preparation, Characterization, and Anti-Arthritic, Anti-Inflammatory, and Antioxidant Activities in Chemically Induced Arthritic Rats / A. Belal et al. Pharmaceuticals. 2023. Vol. 16, no. 4. P. 551. URL: https://doi.org/10.3390/ph16040551.
Das A., Dobbidi P. Impedance Spectroscopy and ac Conductivity in Ba0.5Sr0.5TiO3–Ca10(PO4)6(OH)2 Ceramic Composites: An Electrical Approach to Unveil Biocomposites. ACS Biomaterials Science & Engineering. 2021. Vol. 7, no. 6. P. 2296–2308. URL: https://doi.org/10.1021/acsbiomaterials.1c00009.
Singh S., Singh G., Bala N. Synthesis and characterization of iron oxide-hydroxyapatite-chitosan composite coating and its biological assessment for biomedical applications. Progress in Organic Coatings. 2021. Vol. 150. P. 106011. URL: https://doi.org/10.1016/j.porgcoat.2020.106011.
Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods / T. Tite et al. Materials. 2018. Vol. 11, no. 11. P. 2081. URL: https://doi.org/10.3390/ma11112081.
Ferdous Z., Nemmar A. Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure. International Journal of Molecular Sciences. 2020. Vol. 21, no. 7. P. 2375. URL: https://doi.org/10.3390/ijms21072375.
Yang C.-W., Wang G.-K. Effect of Hydrothermal (Sr)-Hydroxyapatite Coatings on the Corrosion Resistance and Mg2+ Ion Release to Enhance Osteoblastic Cell Responses of AZ91D Alloy. Materials. 2020. Vol. 13, no. 3. P. 591. URL: https://doi.org/10.3390/ma13030591.
Karpiński T. M., Paczkowska-Walendowska M., Cielecka-Piontek J. Nano-Hydroxyapatite-Based Mouthwash for Comprehensive Oral Care: Activity Against Bacterial and Fungal Pathogens with Antioxidant and Anti-Inflammatory Action. Materials. 2025. Vol. 18, no. 15. P. 3567. URL: https://doi.org/10.3390/ma18153567.
Voronina, L. M., Desenko, V. F. (2000) Biolohichna khimiia [Biological Chemistry]. Ternopil: Vyd-vo NFAU, 600 p [in Ukrainian].
Cichoric Acid–Loaded Hydroxyapatite Nanorods Remodel the Immune Microenvironment to Enhance Bone Regeneration / X. Lin et al. Phytomedicine. 2025. P. 157701. URL: https://doi.org/10.1016/j.phymed.2025.157701.
