ТЕХНОЛОГІЧНІ АСПЕКТИ ПРОМИСЛОВОГО КУЛЬТИВУВАННЯ РЕКОМБІНАНТНИХ КЛІТИН-ПРОДУЦЕНТІВ МОНОКЛОНАЛЬНИХ АНТИТІЛ
Ключові слова:
monoclonal antibodies, CHO cells, bioreactors, fed-batch, perfusion culture, recombinant proteins.Анотація
This paper deals with a review of the technological aspects of the industrial cultivation of recombinant cells producing monoclonal antibodies. The key parameters of fed-batch and perfusion bioreactor systems, culture media optimization, and process control strategies are analyzed. The aspects of scaling up the fermentation processes and maintaining product quality attributes to reduce production costs are described.
Посилання
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