MODERN APPROACHES TO THE DESIGN AND OPTIMISATION OF REACTORS FOR PHARMACEUTICAL MANUFACTURING IN THE TRANSITION TO CONTINUOUS PROCESSES AND MICROGRAVITY RESEARCH
Ключові слова:
batch reactors, plug flow reactors, microgravity biofilm reactorАнотація
Different reactor types were examined, including batch reactors whose optimization involved studying equipment design and operating variables—traditionally under the assumption of perfect mixing. To account for non‑idealities in batch reactors, a cell‑model approach was proposed. In continuous processes, plug‑flow (tubular) reactors are widely used, where engineers strive to achieve ideal displacement (plug‑flow) conditions. Separately, biofilm reactors under simulated micro‑gravity were analysed to investigate biofilm growth in spaceflight environments.
Посилання
Hu C. Reactor design and selection for effective continuous manufacturing of pharmaceuticals. Journal of flow chemistry. 2021. Vol. 11. P. 243–263. URL: https://doi.org/10.1007/s41981-021-00164-3.
Zhang J., Smith R. Design and optimisation of batch and semi-batch reactors. Chemical engineering science. 2004. Vol. 59, no. 10. P. 2051–2064. URL: https://doi.org/10.1016/j.ces.2003.10.004.
Adiabatic plug flow reactors and processes incorporating the same : patent U.S. Patent No. US10189756B2. URL: https://patents.google.com/patent/US10189756B2.
A simulated microgravity biofilm reactor with integrated microfabricated sensors: advancing biofilm studies in near-space conditions / H. M. Ketteler et al. Biofilm. 2025. Vol. 9. P. Article 100263. URL: https://doi.org/10.1016/j.biofilm.2025.100263.
Steinberg L. M., Kronyak R. E., House C. H. Coupling of anaerobic waste treatment to produce protein- and lipid-rich bacterial biomass. Life sciences in space research. 2017. Vol. 15. P. 32–42. URL: https://doi.org/10.1016/j.lssr.2017.07.006.
