ВИВЧЕННЯ ДИФЕРЕНЦІЙНОЇ ЕКСПРЕСІЇ ГЕНІВ У ПЛАЦЕНТІ ЗА ФІЗІОЛОГІЧНОЇ ВАГІТНОСТІ
Ключові слова:
placenta, microarray, gene expression, logFC, π-valueАнотація
This study focuses on the identification and functional interpretation of genes with significantly altered expression in the placenta between the first and second trimesters and third and second trimesters of pregnancy. Differential expression analysis was performed using microarray data and visualized via MA and Volcano plots. Top 20 DE-genes were selected based on log2FC and adjusted P-value and functionally annotated. The findings contribute to understanding molecular changes in normal placenta and may have future diagnostic value.
Посилання
Lykhenko O.K., Frolova A.O., Obolenskaya M.Yu. Changes in the human placental transcriptome during the physiological course of pregnancy. Biopolymers and Cell. 2021; 37(1):73–82. doi:10.7124/bc.000a4d
Than N.G., Balogh A., Romero R. et al. Impaired placental immunoregulation and the pathogenesis of preeclampsia. Nature Reviews Nephrology. 2022; 18:466–484
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Ritchie M.E., Phipson B., Wu D. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Research. 2015; 43(7):e47.
