3D-БІОДРУК ЕНДОМЕТРІАЛЬНИХ КОНСТРУКЦІЙ ДЛЯ ФУНКЦІОНАЛЬНОГО ВІДНОВЛЕННЯ МАТКИ
Ключові слова:
endometrial regeneration, 3D bioprinting, microspheres, stem cellsАнотація
This paper presents a literature analysis of biofabrication strategies for bilayer endometrial scaffolds, comparing hydrogel-based drug delivery systems and stem cell-loaded scaffolds. We examine biomaterial formulations, cellular compositions, release kinetics, and in vitro/in vivo functional outcomes to determine optimal approaches to uterine tissue regeneration.
Посилання
Current advances in understanding endometrial epithelial cell biology and therapeutic applications for intrauterine adhesion / J. Wang et al. Stem cell research & therapy. 2024. Vol. 15, no. 1. URL: https://doi.org/10.1186/s13287-024-03989-6.
3D-printed hydrogel scaffold-loaded granulocyte colony-stimulating factor sustained-release microspheres and their effect on endometrial regeneration / J. Wen et al. Biomaterials science. 2022. URL: https://doi.org/10.1039/d2bm00109h.
A collagen scaffold loaded with human umbilical cord-derived mesenchymal stem cells facilitates endometrial regeneration and restores fertility / L. Xin et al. Acta biomaterialia. 2019. Vol. 92. P. 160–171. URL: https://doi.org/10.1016/j.actbio.2019.05.012.
3D Bioprinting a human iPSC-derived MSC-loaded scaffold for repair of the uterine endometrium / W. Ji et al. Acta biomaterialia. 2020. Vol. 116. P. 268–284. URL: https://doi.org/10.1016/j.actbio.2020.09.012.
3D bio-printed endometrial construct restores the full-thickness morphology and fertility of injured uterine endometrium / N. Nie et al. Acta biomaterialia. 2022. URL: https://doi.org/10.1016/j.actbio.2022.12.016.