REGULATION OF CRISPR-CAS TYPE III ACTIVITY BY MEMBRANE-ASSOCIATED PROTEINS WITH CARF AND SAVED DOMAINS
Анотація
The type III CRISPR-Cas system is a prokaryotic adaptive immune system that confers immunity against invading mobile genetic elements (MGEs). This system involves the use of a multi-subunit effector complex to target foreign DNA transcripts complementary to a guide/CRISPR RNA (crRNA). Type III CRISPR-Cas has an additional layer of protection that includes the production of signaling molecules and effector proteins that respond to them. This system provides a wide range of potential defense pathways involving nucleases, transcription factors, proteases, deaminases, and membrane-associated proteins. Therefore, tight and specific regulation of the activation of accessory proteins has evolved, exhibiting properties such as signal amplification, autoregulation, and tuning the concentration of signaling molecules.
Посилання
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